产品说明
应用
ML-9 has been used in the inhibition of myosin light chain kinase (MLCK) and non-muscle myosin IIA (NMIIA) in human corneal epithelial cells and HeLa cells.
包装
5 mg in glass bottle
生化/生理作用
ML-9 is myosin light chain kinase inhibitor. It inhibits insulin-induced translocation of glucose transporters GLUT4 and GLUT1 in a dose-dependent manner. ML-9 also inhibits agonist-induced Ca2+ entry into endothelial cells and catecholamine secretion in intact and permeabilized chromaffin cells. ML-9 promotes cell death in cancer cells by triggering accumulation of autophagic vacuoles. ML-9 impacts phosphorylation of myosin light chain kinase and alters trabecular meshwork shape and decreases intraocular pressure in rabbit eyes.
特点和优势
This compound is featured on the Ca/CaMKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
基本信息
| 线性分子式 | C15H17N2O2SCl · HCl |
| 分子量 | 361.29 |
| MDL编号 | MFCD00065525 |
| PubChem化学物质编号 | 24278297 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 200 |
| 生物来源 | synthetic (organic) |
| 测定 | ≥99% (TLC) |
| 形式 | powder |
| 颜色 | white |
| 溶解性 | ethanol: 10 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | Cl.Clc1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3 |
| InChI | 1S/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H |
| InChI key | ZNRYCIVTNLZOGI-UHFFFAOYSA-N |
| Gene Information | human ... SLC2A1(6513), SLC2A4(6517) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
