产品说明
Amino Acid Sequence
BOC-Val-Pro-Arg-AFC
一般描述
Thrombin has procoagulant and anticoagulant properties. It also has chemotactic and mitogenic effects. Thrombin triggers the growth of mammalian cells, fibroblasts and macrophage- like tumor cell lines. It regulates brain development. Thrombin plays an important role in hemostasis and thrombosis. It is associated with mast cell degranulation along with the release of histamine and enhances the production of IL-1 (interleukin-1) by activated macrophages. Thrombin stimulates vascular permeability and transendothelial cell migration by neutrophils.
应用
Thrombin is a serine protease involved in the coagulation cascade wherein it converts fibrinogen into fibrin. Thrombin may be detected (assayed) using peptides that contain the VPR sequence such as the fluorogenic substrates Boc-VPR-AFC, Boc-Val-Pro-Arg-7-AMC and the chromogenic substrate Boc-Val-Pro-Arg-pNA. These substrates may also be useful to detect other serine proteases.
基本信息
经验(实验)分子式 | C31H42N7O7 |
分子量 | 624.71 |
NACRES | NA.32 |
产品性质
测定 | ≥95% (HPLC) |
形式 | lyophilized |
组成 | Peptide Content, ≥80% |
储存条件 | protect from light |
储存温度 | −20℃ |