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Thrombin Substrate, fluorogenic

品牌
Sigma-Aldrich
货号
SCP0252
包装型号
规格纯度
参考价格
3627.3 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

Amino Acid Sequence

BOC-Val-Pro-Arg-AFC

一般描述

Thrombin has procoagulant and anticoagulant properties. It also has chemotactic and mitogenic effects. Thrombin triggers the growth of mammalian cells, fibroblasts and macrophage- like tumor cell lines. It regulates brain development. Thrombin plays an important role in hemostasis and thrombosis. It is associated with mast cell degranulation along with the release of histamine and enhances the production of IL-1 (interleukin-1) by activated macrophages. Thrombin stimulates vascular permeability and transendothelial cell migration by neutrophils.

应用

Thrombin is a serine protease involved in the coagulation cascade wherein it converts fibrinogen into fibrin. Thrombin may be detected (assayed) using peptides that contain the VPR sequence such as the fluorogenic substrates Boc-VPR-AFC, Boc-Val-Pro-Arg-7-AMC and the chromogenic substrate Boc-Val-Pro-Arg-pNA. These substrates may also be useful to detect other serine proteases.

基本信息

经验(实验)分子式C31H42N7O7
分子量624.71
NACRESNA.32

产品性质

测定≥95% (HPLC)
形式lyophilized
组成Peptide Content, ≥80%
储存条件protect from light
储存温度−20℃

Sigma-Aldrich

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