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PDE2A Active human

品牌
Sigma-Aldrich
货号
SRP0260
规格纯度
recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE)
参考价格
8831.52 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Phosphodiesterase 2A (PDE2A) is encoded by the gene mapped to human chromosome 11q13.4. The encoded protein belongs to the PDE superfamily.[34}

应用

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

生化/生理作用

Phosphodiesterase 2A (PDE2A) plays a vital role in signal transduction. Activated myocardial PDE2 is considered as a potential intracellular antiadrenergic therapeutic method in heart failure (HF). The encoded protein facilitates growth and invasion of the human malignant melanoma PMP cell line. Thus, suppressing PDE2A activity might be considered as a potential method for hindering growth and invasion of malignant tumor cell lines.

单位定义

One unit is defined as the amount of enzyme that will convert 1 pmole of 3′, 5′-cAMP to 5′ AMP per min at 30℃

外形

Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol and 3 mM DTT.

制备说明

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70℃. Note: Enzyme is very sensitive to freeze/thaw cycles.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in baculovirus infected insect cells
测定≥70% (SDS-PAGE)
形式aqueous solution
specific activity≥2080 pmol/min-μg
分子量 132 kDa
包装pkg of 5 μg
浓度>0.02 mg/mL
NCBI登记号NM_002599
UniProt登记号O00408
运输dry ice
储存温度−70℃
Gene Informationhuman ... PDE2A(5138)

Sigma-Aldrich

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