产品说明
一般描述
A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC50 ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380). Prevents HSV replication both in Vero cells (IC50 ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo. The solid form of this compound (Cat. No. 324895) is also available.
包装
5 mg in Glass bottle
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Primary Target
eIF-2α
警告
Toxicity: Irritant (B)
外形
A 50 mM (5 mg/208 µL) solution of eIF-2α Inhibitor, Salubrinal (Cat. No. 324895) in DMSO.
重悬
Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
其他说明
Boyce, M., et al. 2005. Science307, 935.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C21H17Cl3N4OS |
| 分子量 | 479.81 |
| MDL编号 | MFCD00548612 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | liquid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| SMILES string | S=C(NC(NC(/C=C/C1=CC=CC=C1)=O)C(Cl)(Cl)Cl)NC2=CC=CC3=C2N=CC=C3 |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | 188.6 °F - (refers to pure substance) |
| 闪点(C) | 87 ℃ - (refers to pure substance) |
