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Adenosine 3',5'-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt-Calbiochem

品牌
Sigma-Aldrich
货号
116816
规格纯度
A potent, cell-permeable, and reversible metabolically-stable cAMP antagonist that inhibits cAMP-dependent protein kinase and shows preference for PKA type I.
参考价格
10055.5 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Note: 5 µmol = 2.23 mg.
Cell-permeable, potent, reversible, and metabolically stable antagonist of cAMP that is resistant to the action of mammalian cyclic nucleotide phosphodiesterases. Rp-8-Br-cAMPS is more lipophilic as compared to 8-Br-cAMP and Rp-cAMPS. In contrast to other common ATP-site inhibitors or to its parent compound Rp-cAMPS, Rp-8-Br-cAMPS discriminates between both isozymes of protein kinase A, preferring type I, thus providing additional selectivity. By occupying cAMP binding sites, prevents dissociation and activation of the kinase holoenzyme. λ = 264 nm (H2O, pH 7.0); εmax 17,000 M-1cm-1.
A potent, cell-permeable, and reversible metabolically-stable cAMP antagonist that inhibits cAMP-dependent protein kinase and shows preference for PKA type I. More lipophilic than cAMP antagonist Rp-cAMPS (Cat. No. 116814).

包装

5 μmol in Plastic ampoule

生化/生理作用

Cell permeable: yes
Primary Target
PKA 1
Product does not compete with ATP.
Reversible: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Calaghan, S.C., et al. 1999. Pflugers Arch. 437, 780.
Gjertsen, B.T., et al. 1995. J. Biol. Chem. 270, 20599.
Yokozaki, H., et al. 1992. Cancer Res.52, 2504.
Dostmann, W.R. et al. 1990. J. Biol. Chem.265, 10484.

法律信息

Sold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C10H10BrN5O5PS · Na
分子量446.15

产品性质

质量水平100
测定≥99% (HPLC)
形式lyophilized
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
溶解性water: 40 mg/mL
运输ambient
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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