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Scriptaid-CAS 287383-59-9-Calbiochem

品牌
Sigma-Aldrich
CAS
287383-59-9
货号
565730
规格纯度
A relatively non-toxic, cell-permeable hydroxamic acid-containing histone deacetylase (HDAC) inhibitor.
参考价格
2671.25 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A relatively non-toxic, cell-permeable hydroxamic acid-containing histone deacetylase (HDAC) inhibitor. Facilitates transcriptional activation (TGFβ/Smad4) in both stable and transient receptor assays in a concentration-dependent manner. At ~2 µg/ml (6-8 µM) concentrations, results in a greater than 100-fold increase in histone acetylation in PANC-1 cells. Reported to derepress hTERT by inhibiting the recruitment of HDAC into E2F-pocket protein complexes assembled on the hTERT promoter.
A relatively non-toxic hydroxamic acid-containing histone deacetylase (HDAC) inhibitor. Facilitates transcriptional activation (TGFβ/Smad4) in both stable and transient reporter assays in a concentration-dependent manner. Useful agent for transfection assays in reporter systems due to the lack of interference with the ability of reporter construct to measure positive activation of transcription factor in response to signal transduction stimulus. It causes over 100-fold increase in histone acetylation in PANC-1 cells at 2 µg/ml (6 µM). Reported to derepress hTERT by inhibiting the recruitment of HDAC into E2F-pocket protein complexes assembled on the hTERT promoter.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
HDAC
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Won, J., et al. 2004. Proc. Natl. Acad. Sci. USA101, 11328.
Su, G.H., et al. 2000. Cancer Res.60, 3137.

法律信息

Sold under license of U.S. Patent 6,544,957.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C18H18N2O4
分子量326.35

产品性质

质量水平100
测定≥95% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 off-white
溶解性DMSO: 4 mg/mL
运输ambient
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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