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Bax Channel Blocker-CAS 335165-69-0-Calbiochem

品牌
Sigma-Aldrich
CAS
335165-69-0
货号
196805
规格纯度
A cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties.
参考价格
2096.01 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties. Effectively blocks Bid-induced cyctochrome c release from HeLa cell mitochondria (~80% inhibition at 5 µM) by inhibiting Bax channel-forming activity (IC50 = 520 nM in a liposome channel assay).
A cell-permeable dibromocarbazole-piperazinyl derivative that displays anti-apoptotic properties. Reported to effectively block Bid-induced cytochrome c release from HeLa cell mitochondria (~80% inhibition at 5 µM) by inhibiting Bax channel activity.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
Bax-channel forming activity
Product does not compete with ATP.
Target IC50: 520 nM blocks Bid-induced cyctochrome c release from HeLa cell mitochondria by inhibiting Bax channel-forming activity in a liposome channel assay
Cell permeable: yes
Reversible: no

警告

Toxicity: Carcinogenic / Teratogenic (D)

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Peixoto, P., et al. 2009. Biochem J.423, 381.
Bombrun, A., et al. 2003. J. Med. Chem.46, 4365.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C19H21Br2N3O
分子量467.20

产品性质

质量水平100
测定≥95% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
protect from light
颜色 off-white
溶解性DMSO: 10 mg/mL
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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