产品说明
一般描述
A peptidyl toxin present in the venom of African tarantula, Hysterocrates gigas that acts as a high affinity, reversible blocker of Cav2.3 (α1E, R-type) channels (IC50 = 15-30 nM). The inhibition appears to be voltage-dependent. At lower concentrations it is also shown to block native R-type Ca2+ current in rat neurohypophyseal nerve terminals, however, these effects are not observed at higher concentrations. Does not affect Na+ or K+ currents in several cultured cell types (~ 500 nM).
生化/生理作用
Primary Target
Cav2.3 channels
警告
Toxicity: Standard Handling (A)
序列
GVDKAGCRYMFGGCSVNDDCCPRLGCHSLF→SYCAWDLTFSD (difulfid bond: 7-21, 14-26, 20-33)
重悬
Following reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Abitbol, K. et al. 2012. J. Physiol.590, 2977.
Newcomb, R., et al., 1998. Biochemistry.37, 15353.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C192H274N52O60S7 |
| 分子量 | 4495.00 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| 效能 | 15-30 nM IC50 |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze protect from light |
| 颜色 | white |
| 储存温度 | −20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
