产品说明
一般描述
W146 is a sphingosine-1-phosphate 1 (S1P1) selective antagonist.
Compound 2a is a selective antagonist for human S1P1 (hS1P1) receptor activation by the physiological agonist S1P.
应用
W146 has been used:
- to verify the mode of action of sphingosine-1-phosphate (S1P) in human bone marrow derived mesenchymal stem cells (hMSCs ) and primary human hepatogenic profibrotic cells (hHPCs)
- to study oxidative stress and drug treatment in granulosa cells
- to evaluate its effects on transendothelial electrical resistance (TEER)
生化/生理作用
W146 acts as an orthosteric antagonist. It is linked to blood lymphopenia and lung edema in mice.
包装
5 mL Amber Glass Screw Cap Vial (857390P-10mg)
5 mL Amber Glass Screw Cap Vial (857390P-1mg)
基本信息
经验(实验)分子式 | C18H28F3N2O6P |
分子量 | 456.39 |
NACRES | NA.25 |
产品性质
测定 | >99% (TLC) |
形式 | powder |
包装 | pkg of 1 × 1 mg (857390P-1mg) pkg of 1 × 10 mg (857390P-10mg) |
manufacturer/tradename | Avanti Polar Lipids 857390P |
运输 | dry ice |
储存温度 | −20℃ |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 3 |
闪点(F) | No data available |
闪点(C) | No data available |