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24(S)-Hydroxycholesterol

品牌
Avanti
CAS
474-73-7
货号
700061P
规格纯度
cholest-5-ene-3β,24(S)-diol, powder
参考价格
4213.19 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

24(S)-hydroxycholesterol (24HC) is synthesized from cholesterol in brain dendrites by the action of enzyme cholesterol 24-hydroxylase (CYP46A1). It is catabolized to bile acids in the liver.

应用

24(S)-hydroxycholesterol has been used as an internal standard:

  • in ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS)
  • in liquid chromatography with tandem mass spectrometry (LC-MS/MS) for the quantification of 27-hydroxycholesterol from colorectal tumor samples
  • for quantification of human plasma sterols by liquid chromatography with tandem mass spectrometry (LC MS/MS)

生化/生理作用

24(S)-hydroxycholesterol (24HC) elevated levels are reported in liver inflammation and fibrosis. It is a N-methyl-D-aspartate receptor (NMDAR) modulator. The levels of 24HC are potential indicators of brain development as well as pathology including Alzheimer′s disease (AD) and multiple sclerosis. Polymorphism in the cholesterol 24-hydroxylase (CYP46A1) gene leads to elevated 24HC levels and toxicity. 24HC is a mediator of apoptosis and necroptosis. Elevated levels of 24HC are reported in liver inflammation and fibrosis.

包装

5 mL Amber Glass Screw Cap Vial (700061P-5mg)
5 mL Amber Glass Screw Cap Vial (700061P-1mg)

基本信息

经验(实验)分子式C27H46O2
分子量402.65
NACRESNA.25

产品性质

测定>99% (TLC)
形式powder
包装pkg of 1 × 1 mg (700061P-1mg)
pkg of 1 × 5 mg (700061P-5mg)
manufacturer/tradenameAvanti Polar Lipids 700061P
运输dry ice
储存温度−20℃
InChI1S/C27H46O2/c1-17(2)25(29)11-6-18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20+,21+,22-,23+,24+,25+,26+,27-/m1/s1
InChI keyIOWMKBFJCNLRTC-XWXSNNQWSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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