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InSolution Caspase-3 Inhibitor I, Cell-Permeable-Calbiochem

品牌
Sigma-Aldrich
货号
235427
规格纯度
The InSolution Caspase-3 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.
参考价格
3614.11 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable inhibitor of caspase-3. The C-terminal DEVD-CHO sequence of this peptide is a highly specific, potent, and reversible inhibitor of caspase-3 (Ki<1 nM) that has also been shown to strongly inhibit PARP cleavage in cultured human osteosarcoma cell extracts (IC50 = 200 pM). The N-terminal sequence (residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide.

包装

1 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Primary Target
caspase-3
Target IC50: 200 pM inhibiting PARP cleavage in cultured human osteosarcoma cell extracts
Product does not compete with ATP.
Reversible: yes
Cell permeable: yes

警告

Toxicity: Irritant (B)

序列

Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO

外形

A 5 mM (1 mg/100 µl) solution of Caspase-3 Inhibitor I, Cell-permeable (Cat. No. 235423) in DMSO.

重悬

Following initial thaw, aliquot, purge with inert gas, and freeze (-20°C).

其他说明

Lin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305.
Nicholson, D.W. 1996. Nature Biotechnol. 14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem.271, 1841.
Lin, Y.-Z., et al. 1995. J. Biol. Chem.270, 14255.
Nicholson, D.W., et al. 1995. Nature 376, 37.
Tewari, M., et al. 1995. Cell 81, 801.
Lazebnik, Y.A., et al. 1994. Nature371, 346.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C94H158N20O27
分子量2000.38

产品性质

质量水平100
测定≥90% (HPLC)
形式liquid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
protect from light
运输wet ice
储存温度−20℃

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)188.6 °F - (Dimethylsulfoxide)
闪点(C)87 ℃ - (Dimethylsulfoxide)

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