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InSolution PD 98059-CAS 167869-21-8-Calbiochem

品牌
Sigma-Aldrich
CAS
167869-21-8
货号
513001
规格纯度
InSolution PD 98059, CAS 167869-21-8, is a 5 mg/ml solution in DMSO. A a cell-permeable, selective & reversible inhibitor of MAP Kinase Kinase (MEK).
参考价格
2165.23 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Selective and cell-permeable inhibitor of MAP kinase kinase (MEK) that acts by inhibiting the activation of MAP kinase and subsequent phosphorylation of MAP kinase substrates. Pretreatment of PC-12 cells with PD 98059 completely blocks the 4-fold increase of MAP kinase activity produced by nerve growth factor (NGF; IC50 = 2 µM); however, it has no effect on NGF-dependent tyrosine phosphorylation of the pp140trk receptor or its substrate Shc and does not block NGF-dependent activation of PI 3-kinase. Inhibits cell growth and reverses the phenotype of ras-transformed BALB 3T3 mouse fibroblasts and rat kidney cells.

包装

1 ml in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC50: 2 µM in completely blocking the 4-fold increase in MAP kinase activity produced by nerve growth factor in PC12 cells
Primary Target
MAP kinase kinase (MEK)
Product does not compete with ATP.
Reversible: yes

警告

Toxicity: Irritant (B)

外形

A 5 mg/ml solution of PD 98059 (Cat. No. 513000) in anhydrous DMSO.

重悬

Following initial thaw, aliquot and freeze.

其他说明

Kültz, D., et al. 1998. J. Biol. Chem.273, 13645.
Dudley, D.T., et al. 1995. Proc. Natl. Acad. Sci. USA92, 7686.
Langlois, W.J., et al. 1995. J. Biol. Chem.270, 25320.
Pang, L., et al. 1995. J. Biol. Chem.270, 13585.
Waters, S.B., et al. 1995. J. Biol. Chem.270, 20883.



Selected Citations
Lee, J., et al. 2009. Cell Stem Cell5, 76.


法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C16H13NO3
分子量267.28
MDL编号MFCD00671789

产品性质

质量水平100
测定≥98% (HPLC)
形式liquid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
运输wet ice
储存温度−20℃
InChI1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
InChI keyQFWCYNPOPKQOKV-UHFFFAOYSA-N

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 2

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