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IKK Inhibitor II, Wedelolactone-CAS 524-12-9-Calbiochem

品牌
Sigma-Aldrich
CAS
524-12-9
货号
401474
规格纯度
The IKK Inhibitor II, Wedelolactone, also referenced under CAS 65646-68-6, controls the biological activity of IKK. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
参考价格
1903.37 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Cell-permeable. The naturally-occuring active ingredient from the herbal medicine, Eclipta alba, that acts as a selective and irreversible inhibitor of IKKα and IKKβ kinase activities (IC50<10 µM). Inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Does not affect the activities of p38 MAP kinase or Akt.
The naturally isolated active ingredient of the herbal medicine, Eclipta alba, that acts as a cell permeable, selective and irreversible inhibitor of IKKα and β kinase activity (IC50<10 µM). Inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Has no effects on p38 MAP kinase or Akt.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
IKKα and β kinase activity
Target IC50: <10 µM against IKKα and β kinase activity
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Kobori, M., et al. 2004. Cell Death Differ.11, 123.
Li, C.C., et al. 2003. J. Org. Chem.68, 8500.
Mors, W.B., et al. 1989. Toxicon27, 1003.
Wagner, H., and Fessler, B. 1986. Planta Med.5, 374.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C16H10O7
分子量314.25
MDL编号MFCD07778564

产品性质

质量水平100
测定≥95% (HPLC)
形式crystalline powder
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 yellow-green
溶解性methanol: 1 mg/mL
DMSO: 5 mg/mL
运输ambient
储存温度2-8℃
InChI1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3
InChI keyXQDCKJKKMFWXGB-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 - P501
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
WGKWGK 1

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