产品说明
一般描述
Cell-permeable. The naturally-occuring active ingredient from the herbal medicine, Eclipta alba, that acts as a selective and irreversible inhibitor of IKKα and IKKβ kinase activities (IC50<10 µM). Inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Does not affect the activities of p38 MAP kinase or Akt.
The naturally isolated active ingredient of the herbal medicine, Eclipta alba, that acts as a cell permeable, selective and irreversible inhibitor of IKKα and β kinase activity (IC50<10 µM). Inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Has no effects on p38 MAP kinase or Akt.
包装
1 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Primary Target
IKKα and β kinase activity
Target IC50: <10 µM against IKKα and β kinase activity
Product does not compete with ATP.
Reversible: no
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Kobori, M., et al. 2004. Cell Death Differ.11, 123.
Li, C.C., et al. 2003. J. Org. Chem.68, 8500.
Mors, W.B., et al. 1989. Toxicon27, 1003.
Wagner, H., and Fessler, B. 1986. Planta Med.5, 374.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C16H10O7 |
| 分子量 | 314.25 |
| MDL编号 | MFCD07778564 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | crystalline powder |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze protect from light |
| 颜色 | yellow-green |
| 溶解性 | methanol: 1 mg/mL DMSO: 5 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
| InChI | 1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3 |
| InChI key | XQDCKJKKMFWXGB-UHFFFAOYSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H302 |
| 预防措施声明 | P264 - P270 - P301 + P312 - P501 |
| 危险分类 | Acute Tox. 4 Oral |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
