产品说明
一般描述
NKX3.1 is a prostate specific androgen-regulated homeobox gene located on chromosome 8.1,2,3 It is difficult to distinguish between high grade prostate adenocarcinoma and high grade infiltrating urothelial carcinoma using hematoxylin and eosin stained specimens.2 Current prostate adenocarcinoma markers such as PSA and PSAP are very useful in determining prostate origin of prostate cancer in other sites, but have lower sensitivity when identifying poorly differentiated compared to well differentiated cases.2 Currently, thrombomodulin and uroplakin are used to identify tumors of urothelial origin; however, their sensitivities are suboptimal.2 In a study by Gurel et al., nearly all cases of metastatic prostate adenocarcinoma were stained by NKX3.1.1 NKX3.1-positive prostate carcinoma cells exhibit nuclear staining.1In another study conducted by Chuang et al., nearly all cases of urothelial carcinoma were negative for NKX3.1.2 Lastly, NKX3.1 has also been found to be expressed in invasive ductal carcinomas (IDC) and invasive lobular carcinomas (ILC) of the breast.3 NKX3.1 expression is limited to ER, PR, and AR positive carcinomas and is more frequently expressed in ILC than IDC.3 NKX3.1 has a high specificity and sensitivity for prostate adenocarcinomas and can be used to help distinguish between prostate carcinoma and urothelial carcinomas.1,2
质量
 IVD |  IVD |  IVD |  RUO |
联系
NKX3.1 Positive Control Slides, Product No. 441S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
制备说明
Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.
Download the latest released IFU
Note: This IFU may not apply to your specific product lot.
其他说明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律信息
Cell Marque is a trademark of sigma-aldrich Co. LLC
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 500 100 |
| 偶联物 | unconjugated |
| 抗体形式 | culture supernatant |
| antibody product type | primary antibodies |
| 克隆 | EP356, monoclonal |
| 描述 | (For In Vitro Diagnostic Use in Select Regions (See Chart)) |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| 包装 | bottle of 1.0 mL predilute (441R-17) bottle of 7.0 mL predilute (441R-18) vial of 0.1 mL concentrate (441R-14) vial of 0.5 mL concentrate (441R-15) vial of 1.0 mL concentrate (441R-16) |
| manufacturer/tradename | Cell Marque™ |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200 |
| 同位素/亚型 | IgG |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
