产品说明
一般描述
PAX-2 is a homeogene strongly expressed during kidney development. PAX-2 gene is expressed in the metanephric mesenchyma after ureter bud induction and is a key factor for the mesenchyma-epithelium conversion. Animals transgenic for PAX-2 have severe renal abnormalities and cysts but no solid tumoral features. The oncogenic potential of the PAX gene family has been reported <em>in vitro</em> with transformation of cell cultures and <em>in vivo</em> with cell injections in nude mice. Gnarra et al. showed PAX-2 expression in renal carcinoma cell lines and underlined its potential role in cell proliferation in these lines.1 Mazal et al. demonstrated PAX-2 nuclear expression in 88% of clear cell renal cell carcinomas as well as 18% of papillary renal cell carcinoma, and 13% of chromophobe renal cell carcinomas.2 More recently, Chivukula et al. demonstrated utility in distinguishing ovarian serous papillary carcinoma (anti-PAX-2 positive) from breast carcinoma (anti-PAX-2 negative).3
质量
 IVD |  IVD |  IVD |  RUO |
联系
PAX-2 Positive Control Slides, Product No. 311S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
制备说明
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其他说明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律信息
Cell Marque is a trademark of sigma-aldrich Co. LLC
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 500 100 |
| 偶联物 | unconjugated |
| 抗体形式 | culture supernatant |
| antibody product type | primary antibodies |
| 克隆 | EP235, monoclonal |
| 描述 | (For In Vitro Diagnostic Use in Select Regions (See Chart)) |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| 包装 | bottle of 1.0 mL predilute (311R-17) bottle of 7.0 mL predilute (311R-18) vial of 0.1 mL concentrate (311R-14) vial of 0.5 mL concentrate (311R-15) vial of 1.0 mL concentrate (311R-16) |
| manufacturer/tradename | Cell Marque™ |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50 |
| 同位素/亚型 | IgG |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
