产品说明
一般描述
Voriconazole is a second-generation triazole, and is derived from fluconazole. It has a broad and enhanced antifungal spectrum as compared to other older triazoles. It is mostly well tolerated and is available in both oral and intravenous formulations.
应用
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
生化/生理作用
Voriconazole is an antifungal used to treat serious fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-a sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes.
伏立康唑是用于治疗严重真菌感染的抗真菌药。伏立康唑通过抑制 CYP450 依赖性 14-α甾醇脱甲基酶来抑制麦角固醇合成，从而导致真菌细胞膜中的麦角固醇减少。
It has been used as one of the constituent of YPD (1% yeast extract, 2% peptone, 2% glucose) liquid media.
法律信息
VETRANAL is a registered trademark of sigma-aldrich Chemie GmbH
基本信息
| 经验(实验)分子式 | C16H14F3N5O |
| 分子量 | 349.31 |
| MDL编号 | MFCD00905717 |
| PubChem化学物质编号 | 329754241 |
产品性质
| 等级 | analytical standard |
| 质量水平 | 100 |
| 产品线 | VETRANAL® |
| 保质期 | limited shelf life, expiry date on the label |
| technique(s) | HPLC: suitable gas chromatography (GC): suitable |
| application(s) | forensics and toxicology pharmaceutical (small molecule) |
| 格式 | neat |
| SMILES string | C[C@@H](c1ncncc1F)[C@](O)(Cn2cncn2)c3ccc(F)cc3F |
| InChI | 1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1 |
| InChI key | BCEHBSKCWLPMDN-MGPLVRAMSA-N |
安全信息
| 象形图 |   |
| 警示用语： | Danger |
| 危险声明 | H301 - H341 - H351 - H361 - H371 - H372 - H373 - H412 |
| 预防措施声明 | P202 - P260 - P264 - P270 - P273 - P301 + P310 |
| 危险分类 | Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 2 - Muta. 2 - Repr. 2 - STOT RE 1 - STOT RE 2 Oral - STOT SE 2 Oral |
| 靶器官 | Eyes |
| 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
