Anti-RBX1 antibody produced in mouse

产品说明

一般描述

Ring-box 1 (RBX1) gene encodes an evolutionarily conserved protein that interacts with cullins. The protein plays a unique role in the ubiquitination reaction by heterodimerizing with cullin-1 to catalyze ubiquitin polymerization. It also may be involved in the regulation of protein turn-over (provided by RefSeq). Ring-box 1 (RBX1) gene is located on human chromosome 22q13.2. RBX1 is a component of SCF (Skp1, Cullins, F-box proteins) E3 ubiquitin ligases. RBX1 is a14 kDa protein with a ring finger domain (C₃H₂C₃), essential for ubiquitin ligation.

免疫原

RBX1 (AAH01466, 1 a.a. ~ 108 a.a) full-length human protein.

Sequence
MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH

生化/生理作用

Ring-box 1 (RBX1) mediates neddylation of cullin-1(CUL1). RBX1 regulates protein turnover. RBX1 is a potential anticancer target. Mutations in RBX1 is linked to tumorigenesis and tumor progression. RBX1 acts as a drug target for esophageal cancer. RBX1 has a role in bladder urothelial cell carcinoma (UCC) carcinogenesis and progression.

外形

Solution in phosphate buffered saline, pH 7.4

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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