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Anti-RFWD2 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB2106611
规格纯度
affinity isolated antibody
参考价格
6140.89 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

免疫原

The immunogen for anti-RFWD2 antibody: synthetic peptide derected towards the middle region of human RFWD2

生化/生理作用

Rfwd2 is an E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It is involved in JUN ubiquitination and degradation and directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Rfwd2 probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1.

序列

Synthetic peptide located within the following region: MSGLYSPVSEDSTVPQFEAPSPSHSSIIDSTEYSQPPGFSGTSQTKKQPW

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 80 kDa
species reactivityhuman, bovine, rat, rabbit, guinea pig, horse, dog
浓度0.5 mg - 1 mg/mL
technique(s)western blot: suitable
NCBI登记号NM_011931
UniProt登记号Q9R1A8
运输wet ice
储存温度−20℃
Gene Informationhuman ... COP1(64326)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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