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PTP Inhibitor V, PHPS1-CAS 314291-83-3-Calbiochem

品牌
Sigma-Aldrich
CAS
314291-83-3
货号
540213
规格纯度
The PTP Inhibitor V, PHPS1, also referenced under CAS 314291-83-3, controls the biological activity of PTP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
参考价格
2340.22 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable phosphotyrosine mimetic that acts as a reversible, active-site targeting, substrate-competitive inhibitor of Shp-2 (IC50 and Ki = 2.1 and 0.73 µM, respectively). PHPS1 inhibits ECPTP, PTP1B, Shp1, mycobacterium MptpA only at higher concentrations (IC50 = 5.4, 19, 30, and 39 µM, respectively) and exhibits little activity against PTPH1, STEP, PTPN7, PTPRK, GLEPP1, or LAR2 even at concentrations as high as 50 µM. Shown to inhibit Shp-2-dependent cellular signaling and tumor cell colonies formation.

包装

10 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

其他说明

Hellmuth, K., et al. 2008. Proc. Natl. Acad. Sci. USA105, 7275.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C21H15N5O6S
分子量465.44

产品性质

质量水平100
测定≥95% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
protect from light
颜色 reddish
溶解性DMSO: 10 mg/mL
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

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