Anti-RGS7 antibody produced in chicken

产品说明

一般描述

RGS7 (regulator of G-protein signaling 7) is a member of the R7 subfamily of RGS superfamily of regulators, and shares high homology with RGS9-2. It is composed of the catalytic RGS domain, a dishevelled, EGL-10 and pleckstrin (DEP) domain in its N-terminal, along with a G protein γ subunit-like (GGL) domain. It is both a soluble cytosolic protein as well as a membrane protein.

免疫原

Immunogen Sequence: GI # 11140809, sequence 227-262
Recombinant regulator of G-protein signalling 7

应用

Anti-RGS7 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

生化/生理作用

Regulator of G-protein signaling 7 belongs to a subfamily of regulator of G protein signaling (RGS) proteins, which modulate G protein signaling by acting as GTPase-activating proteins for G protein α-subunits. RGS7 exists as a dimer with the G protein β(5)-subunit. It plays a major role in the pathogenesis of panic disorder (PD). RGS7 has a potential role in neurons communicating between classical heterotrimeric G protein subunits and/or their effectors at the plasma membrane and the cell nucleus. It helps in regulating signaling by μ-opioid receptor (MOR) and dopamine D2 receptor (D2R) and are implicated in drug addiction, movement disorders and nociception.

外形

Solution in phosphate buffered saline containing 0.02% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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