Anti-GABA B Receptor R1 Antibody

产品说明

一般描述

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.

特异性

Reactivity with other species has not been determined.
Cat. # AB2256 recognizes GABA B Receptor R1 (GABA B R1)

免疫原

Recombinant peptide (aa 972-991: PSEPPDRLSCDGSRVHLLYK)
Epitope: C-Terminus
interaction w/ ATF4

应用

Immunohistochemistry: Working dilution of 1:3,000 in free floating mouse brain tissue.
Detect GABA B Receptor R1 using this Anti-GABA B Receptor R1 Antibody validated for use in WB, IH.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors

质量

Western Blotting: 1:1,000 dilution from a previous lot detected GABA B R1 on 10µg of rat brain lysate.

目标描述

~100-105 kDa

外形

GST-Depleted Sera with 0.05% NaN3.

储存及稳定性

Stable for 1 year at -20ºC from date of receipt.

分析说明

Control
Rat brain lysates

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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