Anti-Integrin β1 Antibody, phospho-specific [Thr788/Thr789]

产品说明

一般描述

Integrin beta1 is a transmembrane glycoprotein that forms noncovalent complexes with various alpha integrin subunits to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumor cells. Interactions between integrins and extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. Phosphorylation of threonines 788 and 789 on integrin beta1 receptor may play a key role in cell-cycle dependent regulation.

特异性

The antibody detects a 130 kDa protein of integrin beta1 receptor.

免疫原

Epitope: pT788/789
Phosphorylated synthetic peptide corresponding to amino acid residues surrounding and including threonine 788/789 of the human beta1 integrin. The immunogen sequence is 100% identical in mouse, rat and chicken integrin beta1.

应用

Western Blot: 1:1000.

Optimal working dilutions must be determined by end user.
Research Category
Cell Structure
Research Sub Category
Integrins
Anti-Integrin β1 Antibody, phospho-specific [Thr788/Thr789] is an antibody against Integrin β1 for use in WB.

联系

Replaces: 04-1109

外形

ImmunoAffinity Purified
Antibody is cross-adsorbed to nonphospho-peptide corresponding to the site of phosphorylation then affinity purified using phosphorylated integrin beta1 receptor (Thr788/789) peptide. Antibody is supplied in Dulbecco′s phosphate-buffered saline (without Mg²⁺ or Ca²⁺), pH 7.3, 50% glycerol and 1 mg/mL BSA.

储存及稳定性

Maintain at -20°C for up to one year from date of receipt. Avoid repeated freeze/thaw cycles.

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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