Anti-Activation-induced cytidine deaminase (AID) Antibody, clone 328.8

产品说明

一般描述

Activation-induced cytidine deaminase (AID) is a 24 kDa, RNA-editing protein that is necessary for the initiation of both somatic hypermutation (SHM) and class switch recombination (CSR) of the Ig gene through the production of U:G mismatches in DNA, and is primarily found in activated B cells. AID expression has also been observed in several varying types of B cell lymphomas such as; Burkitt’s lymphoma, Hodgkin’s lymphoma, hairy cell lymphoma, follicular lymphoma, mantle cell lymphoma, mucosa-associated lymphoid tissue lymphoma, and mediastinal B cell lymphoma. Mutations in AID expression are causal to autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2), which is characterized by serum containing IgM but lacking IgG, IgA and IgE, which leads to severe susceptibility to bacterial infections.

免疫原

KLH-conjugated linear peptide corresponding to human Activation-induced cytidine deaminase (AID).

应用

Anti-Activation-induced cytidine deaminase (AID) Antibody, clone 328.8 detects level of Activation-induced cytidine deaminase (AID) & has been published & validated for use in WB, IH.
Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH. (Matthew Scharff, Albert Einstein, matthew.scharff@einstein.yu.edu.)
Research Sub Category
Immunoglobulins & Immunology
Research Category
Inflammation & Immunology

质量

Evaluated by Western Blot in Raji cell lysate.

Western Blot Analysis: 1:2,000 dilution of this antibody detected Activation-induced cytidine deaminase (AID) on 10 µg of Raji cell lysate.

目标描述

~ 24 kDa observed. Uncharacterized bands may be observed in some lysates.

外形

Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Raji cell lysate

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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