Anti-AMHR2 Antibody, clone 10H8.1

产品说明

一般描述

Anti-Muellerian hormone type-2 receptor (EC 2.7.11.30; UniProt Q16671; also known as Anti-Muellerian hormone type II receptor, AMH type II receptor, MIS type II receptor, MISRII, MRII) is encoded by the AMHR2 (also known as AMHR, MISR2) gene (Gene ID 269) in human. Anti-Müllerian hormone (AMH) or Müllerian inhibiting substance (MIS) is a TGF- family homodimeric glycoprotein hormone. AMH/MIS is responsible for regression of the Müllerian ducts in male embryos, it is also produced in both male and female gonads after birth and plays a role in folliculogenesis, germ cell maturation and gonadal function. AMH/MIS interacts with single membrane-spanning serine/threonine kinase receptors type I (AMHR1/MISRI) and II (AMHR2/MISRII). AMHR1 is nearly ubiquitously expressed, whereas AMHR2 is mainly detected in the gonads and other organs of the reproductive tract. AMHR2 is found expressed in the majority of human granulosa cell tumors (GCTs) and epithelial ovarian cancers (EOCs). In addition, AMHR2 expression is also reported in breast and prostate cancers. Human AMHR2 is produced with a signal peptide (a.a. 1-17), which is removed posttranslationally to yield the mature receptor with an N-terminal extracellular region (a.a. 18-149), a singl-transmembrane domain (a.a. 150-170), and a large cytoplasmic region (a.a. 171-573) that contains the kinase domain (a.a. 203-518; a.a. 230 ATP-binding site; a.a. 333 proton acceptor site; a.a. 209-217 ATP-binding site).

特异性

Clone 10H8.1 targets an extracellular epitope present in all three spliced isoforms of human AMH type II receptor (AMHR2) reported by UniProt (Q16671).

免疫原

GST-tagged recombinant human AMHR2 extracellular domain.

应用

Detect AMHR2 using this mouse monoclonal Anti-AMHR2 Antibody, clone 10H8.1, Cat. No. MABC1213, validated for use in Western Blotting.

质量

Evaluated by Western Blotting in Jurkat cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected AMHR2 in 10 µg of Jurkat cell lysate.

目标描述

~60 kDa observed. 62.75/52.24/51.83 kDa (isoform 1/2/3) calculated. Uncharacterized band(s) may appear in some lysates.

外形

Protein G purified.
Format: Purified

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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