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3,4-Dichloroisocoumarin-CAS 51050-59-0-Calbiochem

品牌
Sigma-Aldrich
CAS
51050-59-0
货号
287815
包装型号
规格纯度
参考价格
2950.71 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A potent irreversible inhibitor of serine proteases. Blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Does not affect thiol proteases and metalloproteases. Also has no activity towards β-lactamases. Effective at concentrations ranging from 5-100 µM.
Effective concentration: 5-100 µM; t½ = 20 min at pH 7.5.
A potent, irreversible inhibitor of serine proteases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Inhibits granzyme B and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Does not affect thiol proteases and metalloproteases. Does not exhibit any activity towards β-lactamases.

包装

10 mg in Plastic ampoule

生化/生理作用

Product does not compete with ATP.
Reversible: no
Primary Target
serine proteases
Cell permeable: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Cain, K., et al. 1994. Biochem. Cell Biol.72, 631.
Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488.
Odake, S., et al. 1991. Biochemistry 30, 2217.
Harper, J.W., et al. 1985. Biochemistry24, 1831.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C9H4Cl2O2
分子量215.03
MDL编号MFCD00036960

产品性质

质量水平100
测定≥99% (elemental analysis)
形式lyophilized solid
效能5-100 μM IC50
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated
颜色 white
溶解性DMF: 10 mM
DMSO: 10 mM
运输ambient
储存温度2-8℃
InChI1S/C9H4Cl2O2/c10-7-5-3-1-2-4-6(5)9(12)13-8(7)11/h1-4H
InChI keySUGXUUGGLDCZKB-UHFFFAOYSA-N

安全信息

象形图GHS06
警示用语:Danger
危险声明H301 - H315 - H319 - H335
预防措施声明P261 - P264 - P270 - P301 + P310 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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