产品说明
一般描述
A potent inhibitor of Janus Protein tyrosine Kinases (JAKs). Displays potent inhibitory activity against JAK1 (IC50 = 15 nM for murine JAK1), JAK2 IC50 = 1 nM), JAK3 (Ki = 5 nM), and Tyk2 (IC50 = 1 nM). It inhibits other kinases only at much higher concentrations. Also inhibits IL-2- and IL-4-dependent proliferation of CTLL cells and blocks the phosphorylation of STAT5.
包装
500 μg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Target Ki: 5 nM against JAK3
Reversible: yes
Cell permeable: yes
Primary Target
murine JAK1
Product competes with ATP.
Target IC50: 15 nM, 1 nM against murine JAK1 and JAK2, respectively; 1 nM against Tyk2
警告
Toxicity: Irritant (B)
外形
A 10 mM (500 µg/162 µl) solution of JAK Inhibitor I (Cat. No. 420099) in DMSO.
重悬
Following initial use, aliquot and refrigerate (4°C).
其他说明
Thompson, J.E., et al. 2002. Bioorg. Med. Chem. Lett.12, 1219.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
经验(实验)分子式 | C18H16FN3O |
分子量 | 309.34 |
产品性质
质量水平 | 100 |
测定 | ≥98% (HPLC) |
形式 | liquid |
manufacturer/tradename | Calbiochem® |
储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
运输 | wet ice |
储存温度 | 2-8℃ |
安全信息
储存分类代码 | 10 - Combustible liquids |
WGK | WGK 2 |
闪点(F) | 188.6 °F - (Dimethylsulfoxide) |
闪点(C) | 87 ℃ - (Dimethylsulfoxide) |