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InSolution JAK Inhibitor I-CAS 457081-03-7-Calbiochem

品牌
Sigma-Aldrich
CAS
457081-03-7
货号
420097
规格纯度
The InSolution JAK Inhibitor I, also referenced under CAS 457081-03-7, controls the biological activity of JAK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
参考价格
1954.93 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A potent inhibitor of Janus Protein tyrosine Kinases (JAKs). Displays potent inhibitory activity against JAK1 (IC50 = 15 nM for murine JAK1), JAK2 IC50 = 1 nM), JAK3 (Ki = 5 nM), and Tyk2 (IC50 = 1 nM). It inhibits other kinases only at much higher concentrations. Also inhibits IL-2- and IL-4-dependent proliferation of CTLL cells and blocks the phosphorylation of STAT5.

包装

500 μg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Target Ki: 5 nM against JAK3
Reversible: yes
Cell permeable: yes
Primary Target
murine JAK1
Product competes with ATP.
Target IC50: 15 nM, 1 nM against murine JAK1 and JAK2, respectively; 1 nM against Tyk2

警告

Toxicity: Irritant (B)

外形

A 10 mM (500 µg/162 µl) solution of JAK Inhibitor I (Cat. No. 420099) in DMSO.

重悬

Following initial use, aliquot and refrigerate (4°C).

其他说明

Thompson, J.E., et al. 2002. Bioorg. Med. Chem. Lett.12, 1219.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C18H16FN3O
分子量309.34

产品性质

质量水平100
测定≥98% (HPLC)
形式liquid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
protect from light
运输wet ice
储存温度2-8℃

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 2
闪点(F)188.6 °F - (Dimethylsulfoxide)
闪点(C)87 ℃ - (Dimethylsulfoxide)

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