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Histone Deacetylase 8, His·Tag®, Human Recombinant, S. frugiperda

品牌
Sigma-Aldrich
货号
382184
规格纯度
Histone Deacetylase 8, His·Tag, Human Recombinant, S. frugiperda, is a full length HDAC8 fused to His-Tag at the C-terminus. Useful in the study of HDAC8 regulation and for inhibitor screening.
参考价格
9059.01 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Full length, recombinant, human histone deacetylase 8 (HDAC8) fused to at the C-terminus to a His•Tag sequence at and expressed in S. frugiperda insect cells using a baculovirus expression system. HDAC8 phosphorylated in vivo by PKA results in decreased activity, which leads to the hyperacetylation of histones H3 and H4. HDAC8 may play a role in one of the most frequent types of acute myeloid leukemia (AML). The active deacetylase is useful in the study of HDAC8 regulation and for inhibitor screening.

包装

50 μg in Plastic ampoule
Please refer to vial label for lot-specific concentration.

警告

Toxicity: Standard Handling (A)

单位定义

One unit is defined as the the amount of enzyme required to deacetylate 1 picomol fluorescent peptide substrate [Arg-His-Lys(Ac)-Lys(Ac)] per min at 30°C.

外形

In 138 mM NaCl, 25 mM Tris-HCl, 10% glycerol, 0.05% TWEEN®-20 detergent, pH 8.0.

重悬

Following initial thaw, aliquot and freeze (-70°C).

其他说明

Waltregny, D., et al. 2005. FASEB J.19, 966.
Buggy, J.J., et al. 2000. Biochem J. 350, 199

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
HIS TAG is a registered trademark of Merck KGaA, Darmstadt, Germany
TWEEN is a registered trademark of Croda International PLC

产品性质

重组expressed in insect cells (S. frugiperda)
质量水平100
测定≥90% (SDS-PAGE)
形式liquid
specific activity≥10 units/μg protein
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
avoid repeated freeze/thaw cycles
运输wet ice
储存温度−70℃

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1

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