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AhR Antagonist-CAS 301326-22-7-Calbiochem

品牌
Sigma-Aldrich
CAS
301326-22-7
货号
182705
规格纯度
The AhR Antagonist, also referenced under CAS 301326-22-7, controls the biological activity of AhR.
参考价格
2741.8 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable pyrazolo-amide compound that potently blocks the binding of TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) to AhR (aryl hydrocarbon receptor) in a dose-dependent manner. Shown to Inhibit TCDD-induced AhR transcription activity in HepG2 cells in vitro (IC50 = 30 nM) and prevent TCDD-elicited liver toxicity and wasting syndrome in mice in vivo. Unlike the commonly used AhR antagonist flavone, this inhibitor has no effect on estrogen receptor transcription activity, nor does it exhibit TCDD-like agonist activity even at concentrations as high as 10 µM.

包装

10 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC50: 30 nM in blocking TCDD-induced AhR transcription activity in HepG2 cells in vitro
Product does not compete with ATP.
Reversible: no
Primary Target
AhR (aryl hydrocarbon receptor)

警告

Toxicity: Irritant (B)

其他说明

Kim, S.H., et al. 2006. Mol. Pharmacol.69, 1871.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C19H19N5O
分子量333.39
MDL编号MFCD00377884

产品性质

质量水平100
测定≥95% (HPLC)
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 orange-brown
溶解性DMSO: 10 mg/mL
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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