产品介绍：
产品说明
包装
10, 50 mg in glass bottle
生化/生理作用
TNCA is a tryptophan derivative that binds the parathyroid Ca2+-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity. TNCA is shown to potentiate both Mg++- and Ca++-evoked cellular calcium response (0.1-0.5 mM), as well as Mg++-evoked cellular ERK1/2 phosphorylation in CaSR-expressing HEK293 cells (0.5 mM). AC-265347 (Cat. No. SML0129), on the other hand, is a calcimimetic that functions as a CaSR agonist.
基本信息
| 经验(实验)分子式 | C12H12N2O2 |
| 分子量 | 216.24 |
| MDL编号 | MFCD00272641 |
| PubChem化学物质编号 | 329826033 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 旋光性 | [α]/D -57 to -67°, c = 1 (in MeOH:1N HCl (1:1)) |
| 颜色 | white to beige |
| 溶解性 | 1.5 mg/mL, clear (Solvent: 0.1N HCl:DMSO (1:1); warmed) |
| 储存温度 | −20℃ |
| SMILES string | O=C(O)[C@H]1NCC2=C(C3=C(N2)C=CC=C3)C1 |
| InChI | 1S/C12H12N2O2/c15-12(16)10-5-8-7-3-1-2-4-9(7)14-11(8)6-13-10/h1-4,10,13-14H,5-6H2,(H,15,16)/t10-/m0/s1 |
| InChI key | FSNCEEGOMTYXKY-JTQLQIEISA-N |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
