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TRIM24 (896-1014) GST tag human

品牌
Sigma-Aldrich
货号
SRP6575
规格纯度
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
参考价格
3563.77 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. TRIM24 is a transcriptional cofactor, whose inactivation leads to hepatocellular carcinoma in mice.3 The N-terminal TRIM domain of TRIM24 binds ligand-bound nuclear receptors, while its tandem C-terminal plant homeo-domain and bromodomain target TRIM24 to acetylated histones in chromatin. This product contains the bromodomain region of TRIM24.

外形

50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in E. coli
测定≥95% (SDS-PAGE)
形式liquid
分子量 40.9 kDa (896-1014 aa + NT GST Tag)
包装pkg of 100 μg
pkg of 20 μg
UniProt登记号O15164
运输dry ice
储存温度−70℃
Gene Informationhuman ... TRIM24(8805)

安全信息

象形图GHS07
警示用语:Warning
危险声明H317 - H319 - H412
预防措施声明P273 - P280 - P305 + P351 + P338 - P333 + P313 - P337 + P313
危险分类Aquatic Chronic 3 - Eye Irrit. 2 - Skin Sens. 1
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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