位置:首页 > 品牌 > Sigma-Aldrich >

Tim-4 (human): FC (human)

品牌
Sigma-Aldrich
货号
SRP8057
规格纯度
recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)
参考价格
8416.19 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-4 (T cell; immunoglobulin; Mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIM-4 is exclusively expressed on antigen-presenting cells, where it mediates phagocytosis of apoptotic cells and plays an important role in maintaining tolerance. TIM-4 binds specifically to TIM-1 which is also the cellular receptor for the hepatitis A virus, and has been implicated in the development of asthma. Among hematopoietic cells, TIM-1 is expressed on activated B and T cells, preferentially in the Th2 subset of CD4+ T cells. The interaction of TIM-4 with TIM-1 induces costimulatory and hyperproliferative signals in T cells.

外形

Lyophilized from 0.2 μm-filtered solution in PBS.

重悬

Reconstitute at 100 μg/mL in sterile PBS.

其他说明

The extracellular domain of human Tim-4 (aa 25-315) is fused to the N-terminus of the Fc region of human IgG1.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in CHO cells
测定≥98% (SDS-PAGE)
形式lyophilized
分子量monomer 58 kDa by calculation
包装pkg of 100 μg
杂质<0.06 EU/μg endotoxin, tested
颜色 white
UniProt登记号Q96H15
运输wet ice
储存温度−20℃
Gene Informationhuman ... TIMD4(91937)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号