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TM-N1324

品牌
Sigma-Aldrich
货号
SML3222
规格纯度
≥98% (HPLC)
参考价格
1191.25 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

TM-N1324 is an agonist of GPR39, a G-protein-coupled receptor activated by Zn2+. GPR39 is a member of the ghrelin receptor family that has been implicated in the control of glucose-induced insulin secretion, pancreatic β-cell differentiation, control of lipolysis in white adipose tissue, and may also be involved in the pathophysiology of depression. TM-N1324 was found to activate human GPR39 with potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively, and murine GPR39 with potencies of 180 nM and 5 nM in the absence and presence of Zn2+. TM-N1324 stimulated gastric somatostatin secretion, indirectly inhibiting ghrelin secretion It showed no agonist activity for 156 other GPCRs tested or for related receptors ghrelin and motilin.

基本信息

经验(实验)分子式C18H13ClFN7O
分子量397.79

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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