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Rabbit anti-ORC1 Antibody, Affinity Purified

品牌
Sigma-Aldrich
货号
PLA0221
规格纯度
Powered by Bethyl Laboratories, Inc.
参考价格
6227.32 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Origin recognition complex 1 (ORC1) is the largest subunit of ORC. The subunits are widely expressed in the human lung, bones, kidney, and uterus. The ORC1 gene is mapped to human chromosome 1p32.3.

免疫原

The epitope recognized by PLA0221 maps to a region between residue 811 and 861 of human origin recognition complex subunit 1 using the numbering given in entry NP_004144.2 (GeneID 4998).

应用

Rabbit anti-ORC1 Antibody, Affinity Purified has been used in immunoblotting (1:2,000).

生化/生理作用

The origin recognition complex (ORC) plays a key role in DNA replication. ORC1 is degraded in the S phase and re-synthesized in the G1 phase of the cell cycle. ORC1 is responsible for cell proliferation, apoptosis, invasion, and migration. ORC1 regulates cyclin E1 (CCNE1) gene expression and is involved in genomic maintenance. Downregulation of ORC1 and cyclins cause Meier–Gorlin syndrome.

外形

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

其他说明

ORC1 (origin recognition complex, subunit 1) is one of six subunits that make up the origin of recognition complex (ORC). The ORC serves as a scaffold for proteins involved in the initiation of DNA replication. Very recently, ORC1 has been found to perform a function independent of its role in DNA replication. In a screen using siRNAs for human ORC proteins to assess their roles in centrosome biology, it was found that ORC1 plays a key role in controlling centriole and centrosome copy number in human cells.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式affinity purified immunoglobulin
antibody product typeprimary antibodies
等级Powered by Bethyl Laboratories, Inc.
species reactivityhuman
technique(s)immunoprecipitation (IP): 2-5 μg/mg
western blot: 1:2,000- 1:10,000
登记号NP_004144.2
UniProt登记号Q13415
运输wet ice
储存温度2-8℃
Gene Informationrabbit ... ORC1(4998)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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