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RAR, γ isoform, GST tagged human

品牌
Sigma-Aldrich
货号
SRP2132
规格纯度
recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
参考价格
5035.36 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Nuclear receptors form the largest known family of transcription factors and have a crucial role in nearly all aspects of vertebrate development and adult physiology by transducing the effects of hormones into transcriptional responses. The family is defined by two domains: (a) the central, highly conserved, DNA-binding domain (DBD) of approx. 66 amino acids, and (b) the C-terminal, structurally conserved, ligand-binding domain (LBD) of approx. 250 amino acids. The amino-terminal regions are least conserved among nuclear receptor sequences. Retinoids, the natural and syntheic derivatives of vitamin A, have been shown to inhibit the growth of many human tumor cells. Although the exact mechanism for this growth suppression remains unknown, the importance of retinoic acid receptors (RARs) and retinoid X receptors (RXRs) have been established in a number of tumor cell models. Three types of RARs have been identified (RAR, RAR, and RAR ) with homologous but slightly different retinoic acid (RA) binding domains. Transactivation assays and retinoid binding assays with RAR, RAR, and RAR have shown that each RAR has a different affinity for RA and RA analogs.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRESNA.26

产品性质

生物来源human
重组expressed in E. coli
测定≥70% (SDS-PAGE)
形式frozen liquid
分子量 ~77 kDa
包装pkg of 10 μg
储存条件avoid repeated freeze/thaw cycles
浓度800 μg/mL
颜色clear colorless
NCBI登记号NM_000966
UniProt登记号P13631
运输dry ice
储存温度−70℃
Gene Informationhuman ... RARG(5916)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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