Rabbit anti-GRLF1/p190RhoGAP Antibody, Affinity Purified

产品说明

免疫原

The epitope recognized by PLA0210 maps to a region between residue 1200 and 1250 of human glucocorticoid receptor DNA binding factor 1 (p190RHOGAP) using the numbering given in entry EAW57452.1 (GeneID 2909).

外形

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

其他说明

GRLF1 (glucocorticoid receptor DNA binding factor 1) was first identified as a factor that binds to the regulatory region of the human glucocorticoid receptor (GR) gene and represses GR transcription. Later, p190RhoGAP was identified as a protein that associates with p120RasGAP and through sequence comparison, p190RhoGAP and GRLF1 were determined to be one and the same. GRLF1/P190RhoGAP functions as a GTPase activating protein (GAP) for the Rho GTPase and plays an essential role in mediating cytoskeletal reorganization in response to growth factor signals. p190RhoGAP possesses an unusual GTP binding domain that may serve to regulate its GAP activity and the subsequent modulation of RhoGTPase activity. P190RhoGAP forms a significant complex with p120RasGAP. This association has been suggested to represent a method for the coordination of the Ras and Rho signaling pathways.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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