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RARβ, ligand binding domain (173-409), GST tagged human

品牌
Sigma-Aldrich
货号
SRP2142
规格纯度
recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
参考价格
5035.36 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Several members of nuclear receptor family are directly associated with human malignancies including breast cancer, prostate cancer and leukemia. The pathogenesis of each of these diseases is underpinned by the activities of a member of the superfamily; estrogen receptor-alpha (ER alpha) in breast cancer, androgen receptor (AR) in prostate cancer, and retinoic acid receptor α (RARα) in acute promyelocytic leukemia. Retinoic acid receptors are important in the regulation of growth and differentiation of epithelial tissues, embryonic and central nervous system development and hematopoiesis. Retinoids mediate their effect by two classes of nuclear receptor proteins, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), that each consists of three isotypes (α, β, and γ) encoded in separate genes. Upon dimerization with RXR, RARs can bind to specific enhancer sequences in the DNA, so-called retinoic acid response elements (RAREs), resulting in transcriptional activation of target genes in the presence of ligand. The retinoic acid receptor alpha gene is the target of chromosomal rearrangements in all cases of acute promyelocytic leukemia (APL). RAR α is a negative regulator of promyelocyte differentiation when not complexed with RA, and stimulates this differentiation when bound to RA.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRESNA.26

产品性质

生物来源human
重组expressed in E. coli
测定≥80% (SDS-PAGE)
形式frozen liquid
分子量 ~53.3 kDa
包装pkg of 10 μg
储存条件avoid repeated freeze/thaw cycles
浓度450 μg/mL
technique(s)ligand binding assay: suitable
颜色clear colorless
NCBI登记号NM_000965
UniProt登记号P10826
运输dry ice
储存温度−70℃
Gene Informationhuman ... RARB(5915)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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