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PPAR δ, ligand binding domain (165-441), GST tagged human

品牌
Sigma-Aldrich
货号
SRP2139
规格纯度
recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
参考价格
4949.94 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

There is evidence that a group of closely related nuclear receptors, called peroxisome proliferator-activated receptors (PPARs), may be involved in chronic diseases such as diabetes, obesity, artherosclerosis and cancer. The PPARs were first cloned as the nuclear receptors that mediate the effects of synthetic compounds called peroxisome proliferators on gene transcription. It soon became clear that eicosanoids and fatty acids can also regulate gene transcription through PPARs. They bind a specific element in the promoter region of target genes only as a heterodimer with the receptor for 9- cis retinoic acid, RXR (retinoid X receptor). Binding of the ligand of either receptor can activate the complex, but binding of both ligands simultaneously is more potent. Three PPAR isotypes have been identified: α, β (also called NUC1) and γ. PPARβ is found in many tissues but the highest expression is in the gut, kidney and heart. PPARβ or PPARδ have received little attention, probably because of the lack of a connection with important clinical manifestations. However, recently PPARβ has been linked to colon cancer (3) and as an inducer of COX-2 expression in carcinogenesis, among other functions. PPAR regulates the expression of acyl-CoA synthetase 2 in the brain, linking PPARβ to basic lipid metabolism. Moreover, it probably participates in embryo implantation and decidualization.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRESNA.26

产品性质

生物来源human
重组expressed in E. coli
测定≥80% (SDS-PAGE)
形式frozen liquid
分子量 ~58.2 kDa
包装pkg of 10 μg
储存条件avoid repeated freeze/thaw cycles
浓度300 μg/mL
颜色clear colorless
NCBI登记号NM_006238
UniProt登记号Q03181
运输dry ice
储存温度−70℃
Gene Informationhuman ... PPARD(5467)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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