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p300-Ch1 (302-531) human

品牌
Sigma-Aldrich
货号
SRP2096
规格纯度
recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
参考价格
5526.14 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The EP300 (E1A binding protein p300) gene is mapped to human chromosome 22q13.2. It codes for a histone acetyltransferase which is ubiquitously expressed.

生化/生理作用

Loss of EP300 (E1A binding protein p300) gene function causes Rubinstein-Taybi syndrome. p300 is essential for cell differentiation, growth and survival. p300 promotes liver stiffness, which is known to induce hepatic stellate cell differentiation to tumor-promoting myofibroblasts.
Human p300 and CBP (CREB binding protein) are highly related transcriptional coactivators. Both proteins have been identified through protein interaction assays. In addition to interacting with variety of cellular factors and onco-proteins, loss of the wild type CBP alleles in isolated tumors suggests that CBP/p300 might serve as tumor suppressors. The ability of p300 to acetylate many transcription factors, including p53, E2F, TFIIE, and TFIIF etc. demonstrated a novel mechanism of targeted p300 regulation of gene expression.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRESNA.26

产品性质

生物来源human
重组expressed in E. coli
测定≥80% (SDS-PAGE)
形式frozen liquid
分子量 ~26 kDa
包装pkg of 10 μg
浓度1000 μg/mL
颜色clear colorless
NCBI登记号NM_001429
UniProt登记号Q09472
运输dry ice
储存温度−70℃
Gene Informationhuman ... EP300(2033)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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