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Pazopanib

帕唑帕尼

品牌
Sigma-Aldrich
货号
SML3104
规格纯度
≥98% (HPLC)
参考价格
780.67 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Pazopanib is an orally active receptor tyrosine kinases inhibitor against VEGFR1/2/3 (IC50 = 10/30/47 nM), PDGFR1/2 (IC50 = 84/71 nM) and c-Kit (IC50 = 74 nM), exhibiting reduced or no potency toward FGFR1/3 (IC50 = 140/130 nM), c-fms (IC50 = 146 nM), and other kinases tested (IC50 from >400 nM to >20 μM). Pazopanib exhibits anti-cancer efficacy in cultures (IC50 from 5 to 15 μg/mL; multiple myeloma migration and survival) and in mice in vivo (30-100 mg/kg/day p.o. against human MM xenografts) via angiogenesis inhibition and apoptosis induction.

基本信息

经验(实验)分子式C21H23N7O2S
分子量437.52
MDL编号MFCD11616589

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear (warmed)
储存温度2-8℃
SMILES stringCN1N=C2C=C(N(C3=NC(NC4=CC=C(C(S(N)(=O)=O)=C4)C)=NC=C3)C)C=CC2=C1C
InChI1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)
InChI keyCUIHSIWYWATEQL-UHFFFAOYSA-N

安全信息

象形图GHS08GHS09
警示用语:Danger
危险声明H360FD - H373 - H411
预防措施声明P202 - P260 - P273 - P280 - P308 + P313 - P391
危险分类Aquatic Chronic 2 - Repr. 1B - STOT RE 2
靶器官Liver
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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