产品说明
一般描述
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
生化/生理作用
Oridonin has potent anti-tumor activity. Oridonin targets AE (AML1-ETO) oncoprotein. Exposure to oridonin induces apoptosis in AE-bearing leukemic cells through the activation of intrinsic apoptotic pathway and triggering a caspase-3-mediated degradation of AE at D188. The compound also prolonged the lifespan of C57 mice bearing truncated AE-expressing leukemic cells without side effects like suppression of bone marrow or reduction of body weight of animals, and exerted synergic effects while combined with cytosine arabinoside. Additionally, oridonin inhibited tumor growth in nude mice inoculated with t(8;21)-harboring Kasumi-1 cells.
法律信息
phyproof is a registered trademark of PhytoLab GmbH & Co. KG
基本信息
| 经验(实验)分子式 | C20H28O6 |
| 分子量 | 364.43 |
产品性质
| 等级 | primary reference standard |
| 产品线 | phyproof® Reference Substance |
| 测定 | ≥98.0% (HPLC) |
| manufacturer/tradename | PhytoLab |
| application(s) | food and beverages |
| 格式 | neat |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
