m-dPEG^®₃₇-NHS ester

产品说明

特点和优势

m-dPEG₃₇-NHS ester is a methyl-terminated, single molecular weight, discrete chain length polyethylene glycol (dPEG) spacer. The carboxylic acid moiety on the end of the molecule opposite the methyl cap is activated with N-hydroxysuccinimide (NHS) for facile reaction with free amines. The dPEG spacer is 112 atoms (133.9 Å) long, a monodisperse equivalent of a polymeric PEG₁₅₀₀. m-dPEG₃₇-NHS ester can be used to modify silica shelled quantum dots to make them water-soluble. Also, it has been employed to improve the pharmacokinetic (PK) and biodistribution (BD) properties of an antibody. Carbon nanotubes and inorganic nanoparticles with amine-functionalized surfaces could also be modified to passivate the surface and make it hydrophilic. Overall, proteins and other biomolecules conjugated to this product will have higher water solubility, reduced or eliminated antigenicity, and improved PK and BD properties.

法律信息

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign

基本信息

产品性质

安全信息