产品介绍：
产品说明
生化/生理作用
Lumateperone tosylate (ITI-007) is an orally active, potent 5-HT2A antagonist, postsynaptic D2 antagonist, and serotonin transporter SERT inhibitor (Ki = 0.5, 32, 62 nM, respectively) with in vivo antipsychotic efficacy and no effect toward receptors associated with cognitive and metabolic side effects of antipsychotic drugs (e.g., H1, 5-HT2C, muscarinic). ITI-007 blocks DOI-induced headtwitch (ID50 = 0.09 mg/kg, po.) and D-AMPH-induced hyperlocomotion in mice (ID50 = 0.95 mg/kg, po.), while also acting as a partial agonist at presynaptic striatal D2 receptors.
基本信息
| 经验(实验)分子式 | C24H28FN3O · C7H8O3S |
| 分子量 | 565.70 |
| MDL编号 | MFCD29922434 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 旋光性 | [α]/D -10 to -14, c = 1 in DMSO |
| 颜色 | white to very dark gray |
| 溶解性 | DMSO: 2 mg/mL, clear |
| 储存温度 | 2-8℃ |
| SMILES string | O=C(C1=CC=C(F)C=C1)CCCN2CC[C@]([C@@]3([H])C2)([H])N4CCN(C)C5=C4C3=CC=C5.O=S(C6=CC=C(C)C=C6)(O)=O |
安全信息
| 象形图 |   |
| 警示用语： | Warning |
| 危险声明 | H336 - H361f |
| 预防措施声明 | P202 - P261 - P271 - P280 - P304 + P340 + P312 - P308 + P313 |
| 危险分类 | Repr. 2 - STOT SE 3 |
| 靶器官 | Central nervous system |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
