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GSK2126458

品牌
Sigma-Aldrich
CAS
1086062-66-9
货号
SML3161
规格纯度
≥98% (HPLC)
参考价格
878.98 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

GSK2126458 (GSK458) is an orally active, highly potent and selective ATP site inhibitor against phosphoinositide 3-kinase (PI3K p110α CI50 = 40 pM; p100 α/δ/γ/β Ki = 19/24/60/130 pM; p110α E542K/E545K/H1047R Ki = 8/8/9 pM), mTOR (mTORC1/C2 Ki = 180/300 pM) and DNA-PK (IC50 = 280 pM) with >10,000-fold selectivity over more than 240 other kinases evaluated. GSK458 inhibits cellular AKT pS473 and growth of breast cancer cells in cultures (pAKT/growth IC50 = 0.41/3 nM/T-47D and 0.18/2.4/BT-474) and in vivo (0.3-3 mg/kg, 5x per wk for 3 wks p.o. in mice).

基本信息

经验(实验)分子式C25H17F2N5O3S
分子量505.50
MDL编号MFCD16038929

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃
SMILES stringFC(C=C1F)=CC=C1S(NC2=CC(C3=CC4=C(C5=CN=NC=C5)C=CN=C4C=C3)=CN=C2OC)(=O)=O

安全信息

象形图GHS07GHS08
警示用语:Danger
危险声明H302 - H361fd - H372
预防措施声明P202 - P260 - P264 - P270 - P301 + P312 - P308 + P313
危险分类Acute Tox. 4 Oral - Repr. 2 - STOT RE 1
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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