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HCV-NS4A/NS3-1b Protease, Histag, strain HC-J4 from hepatitis C virus

品牌
Sigma-Aldrich
货号
SRP2151
规格纯度
recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
参考价格
7018.5 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Persistent infection with hepatitis C virus (HCV) is a common cause of chronic liver disease, including chronic hepatitis, cirrhosis, and hepatocellular carcinoma. HCV is an enveloped, single-stranded RNA virus with a 9.6-kb positive-polarity genome, which encodes a polyprotein precursor of about 3,000 amino acids. The HCV polyprotein is proteolytically processed by cellular and HCV proteases into at least 10 distinct products. NS3 serine protease and helicase as well as NS5B RNA-dependent RNA polymerase are believed to be components of a replication complex responsible for viral RNA replication and have been shown to be essential for the HCV replication in chimpanzees. These HCV enzymes have been the major targets for the development of HCV-specific therapeutics during the past decade. The HCV NS3/4A protease is responsible for cleavage at four sites within the HCV polyprotein to generate the N termini of the NS4A, NS4B, NS5A, and NS5B proteins. It has been shown that the central region (amino acids 21-30) of the 54-residue NS4A protein is essential and sufficient for the enhancement of proteolytic activity of the NS3 serine protease. In recent phase I trials, a 2-3-log reduction of HCV viral load was observed after a 2-day treatment with a serine protease inhibitor, which provided the first proof-of-concept evidence that HCV NS3/4A protease inhibitors could be a new therapeutic option for hepatitis C patients.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRESNA.26

产品性质

生物来源hepatitis C virus
重组expressed in E. coli
测定≥80% (SDS-PAGE)
形式frozen liquid
分子量 ~22.7 kDa
包装pkg of 10 μg
浓度500 μg/mL
颜色 colorless to clear
NCBI登记号X61596
运输dry ice
储存温度−70℃
Gene Informationhepatitis C virus ... HCVgp1(951475)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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