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DNA Methyl transferase 3L (160-387) human

品牌
Sigma-Aldrich
货号
SRP6582
规格纯度
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
参考价格
5434.06 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The DNA methyltransferase 3 (DNMT3) family of DNMT proteins perform intial methylation of cytosines to form 5-methylcytosine at CpG (cytosine-phosphate-guanine) sites on the DNA. Once methylation is established on DNA, DNMT1 protein is responsible for maintaining the CpG methylation pattern during chromosome replication. The DNMT3 family includes the two active members, DNMT3a and DNMT3b, and the regulatory factor DNMT3-like protein (DNMT3L). DNMT3L contains a cysteine-rich, DNMT3/ATRX homology or ATRX-DNMT3-DNMT3L (ADD) domain; however it lacks the proline-tryptophan-tryptophan-proline (PWWP) domain, required for non-specific DNA binding. The ADD domain of DNMT3L is responsible for specifically binding to unmethylated histone H3 lysine 4 (H3K4me0). DNMT3L also lacks the conserved residues in the C-terminal DNA MTase domain of DNMT3a and 3b that are required for activity. However, DNMT3L is required to stimulate the DNA methylation activity of DNMT3a and 3b through interactions with the catalytic domain of DNMT3a and 3b.

外形

50 mM Tris, pH 8.0, containing 150 mM sodium chloride and 20% glycerol.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in E. coli
测定≥95% (SDS-PAGE)
形式liquid
分子量 53.2 kDa (160-387 aa + NT GST Tag)
包装pkg of 10 μg
UniProt登记号Q9UJW3
运输dry ice
储存温度−70℃
Gene Informationhuman ... DNMT3L(29947)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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