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Dapagliflozin propanediol monohydrate

品牌
Sigma-Aldrich
CAS
960404-48-2
货号
SML2758
规格纯度
≥98% (HPLC)
参考价格
679.82 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Dapagliflozin (BMS-512148) is an orally active, potent and selective renal sodium-dependent glucose cotransporter 2 (SGLT2; SLC5A2) inhibitor (human/rat SGLT2 IC50 = 1.1/3 nM vs. human/rat SGLT1 IC50 = 1.39/0.6 μM; R-methyl-D-glucopyranoside (AMG) uptake assay with respective CHO transfectants). Dapagliflozin reduces blood glucose levels (by 55% in streptozotocin (STZ)-induced hyperglycemic rats 5 hrs post 0.1 mg/kg p.o.) by preventing the renal glucose reabsorption process and promoting glucose excretion in urine with good pharmacokinetic properties and oral availability (84% in rats and 83% in dogs, respectively, post 1 mg/kg and 6.6 mg/kg p.o.) in vivo.

基本信息

经验(实验)分子式C21H25ClO6·C3H8O2·H2O
分子量502.98
MDL编号MFCD28167768

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
旋光性[α]/D 20 to 26, c = 0.2 in chloroform-d
储存条件desiccated
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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