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Dehydroevodiamine hydrochloride

8,14-Dihydro-14-methyl-indolo[2′,3′:3,4]pyrido[2,1-b]quinazolin-5(7H)-one hydrochloride

品牌
Sigma-Aldrich
CAS
111664-82-5
货号
SML3190
规格纯度
≥98% (HPLC)
参考价格
727.47 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Dehydroevodiamine is the major alkaloid of Evodia rutaecarpa that exhibit cardiovascular effects such as bradycardia, hypotension, and vasorelaxation. Dehydroevodiamine potently inhibits hERG channels. Apparently it is a blocker of IKr (rapid delayed rectifier current) with proarrhythmic effects in vitro and in vivo. Dehydroevodiamine ameliorates the spatial memory impairment in the scopolamine-induced amnestic rats. It reduced neurotoxicity and the production of A?-induced ROS in primary cortical neurons.

基本信息

经验(实验)分子式C19H15N3O · HCl
分子量337.80

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
储存条件desiccated
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear (warmed)
储存温度2-8℃

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 - P501
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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