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Ataxin3 active human

品牌
Sigma-Aldrich
货号
SRP0445
规格纯度
recombinant, expressed in E. coli, ≥59% (SDS-PAGE)
参考价格
6984.77 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Ataxin3 (ATXN3) is encoded by the gene mapped to human chromosome 14q32. The encoded protein is characterized with a ubiquitin interaction motif (UIM) domain involved in binding mono and/or polyubiquitylated proteins.

应用

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

生化/生理作用

Ataxin3 (ATXN3) is a polyglutamine neurodegenerative disease protein involved in the ubiquitin-proteasome pathway. ATXN3 performs all the functions same as ubiquitin proteases such as, reducing polyubiquitylation of 125I-lysozyme by removing ubiquitin from polyubiquitin chains, cleaving a ubiquitin protease substrate and binding the specific ubiquitin protease inhibitor, ubiquitin-aldehyde. Mutation in the gene has been observed in spinocerebellar ataxia type 3 patients.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in E. coli
测定≥59% (SDS-PAGE)
形式aqueous solution
分子量 42 kDa
包装pkg of 250 μg
NCBI登记号NM_004993
UniProt登记号P54252
运输dry ice
储存温度−70℃
Gene Informationhuman ... ATXN3(4287)

安全信息

象形图GHS07GHS08
警示用语:Danger
危险声明H315 - H319 - H360D
预防措施声明P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
危险分类Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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