产品介绍：
产品说明
应用
AZD-7762 hydrochloride has been used:
- as a checkpoint kinase 1 and 2 (CHK1/2) inhibitor to study its effect on the efficiency of non-homologous end-joining (NHEJ) repair in breast cancer cell lines
- as a CHK1 inhibitor to serve as a positive control for replication stress in the assessment of fork restart events
- as a CHK1/2 inhibitor to study its effects on DNA lesions during mice zygote development
包装
5, 25 mg in glass bottle
生化/生理作用
AZD-7762 is a potent, ATP-competitive inhibitor of Chk1 and Chk2 that enhanced cytotoxicity DNA-damaging agents.
基本信息
| 经验(实验)分子式 | C17H19FN4O2S · HCl |
| 分子量 | 398.88 |
| MDL编号 | MFCD12546135 |
| PubChem化学物质编号 | 329825353 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 储存条件 | desiccated |
| 颜色 | white to light brown |
| 溶解性 | DMSO: 15 mg/mL, clear |
| 储存温度 | −20℃ |
| SMILES string | Cl.NC(=O)Nc1cc(sc1C(=O)N[C@H]2CCCNC2)-c3cccc(F)c3 |
| InChI | 1S/C17H19FN4O2S.ClH/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12;/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24);1H/t12-;/m0./s1 |
| InChI key | WFZBLOIXZRZEDG-YDALLXLXSA-N |
安全信息
| 象形图 |   |
| 警示用语： | Danger |
| 危险声明 | H302 - H318 |
| 预防措施声明 | P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310 |
| 危险分类 | Acute Tox. 4 Oral - Eye Dam. 1 |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
