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Anti-TFE3 antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
SAB4200824
规格纯度
clone TFE3-37, purified from hybridoma cell culture
参考价格
2067.58 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Transcription factor E3 (TFE3), also known as Class E basic helix-loop-helix protein 33 (bHLHe33), is a transcriptional activator that mediates the enhancer-promoter interactions. TFE3 belongs to the MiT family of helix-loop-helix leucine zipper transcription factors, it is ubiquitously expressed and can directly associate with DNA as either homodimer or heterodimer which are formed with two other MiT family members, TFEB or TFEC.
TFE3 serve an important role in cell growth, cell proliferation, cellular adaptation to starvation and cellular response to ER stress. Under nutrient-rich conditions, TFE3 is located in the cytoplasm, and under starvation conditions or treatment with ER stressors, TFE3 rapidly translocates to the nuclear. In the nuclear localization, TFE3 mediates cellular adaptation to stress by simultaneously promoting lysosomal biogenesis, autophagy induction, as well as expression of critical mitochondrial and metabolic regulators. It been shown that TFE3 also participate in the transcriptional regulation of the innate immune response.
Pathogen infections promote TFE3 nuclear translocation, thus inducing In vivo expression of several cytokines and chemokines.

应用

Anti-TFE3 antibody specifically recognizes TFE3 from human, mouse, rat, bovine and canine origin. The antibody may be used in various immunochemical techniques including Immunoblotting (~60 kDa). Detection of the TFE3 band by Immunoblotting is specifically inhibited by the immunizing peptide.

外形

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

其他说明

Unless otherwise stated in our catalog our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

免责声明

This product is for R&D use only, not for drug, household, or other uses.

产品性质

生物来源mouse
抗体形式purified from hybridoma cell culture
克隆TFE3-37, monoclonal
形式buffered aqueous solution
分子量 60 kDa
species reactivitymouse, canine, human, rat, bovine
包装antibody small pack of 25 μL
浓度~1 mg/mL
technique(s)immunoblotting: 1.5-3 μg/mL using human A549 cells extract
同位素/亚型IgG1
UniProt登记号P19532
运输dry ice
储存温度−20℃
Gene Informationhuman ... TFE3(7030)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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